Office of Continuing Medical Education

This online CME activity, in slide talk format covers data from a systematic review conducted to determine the comparative effectiveness of current antibiotic treatments for Clostridium difficile infections, the use of nonstandard interventions for multiple recurrences, and prevention strategies. This CME activity is provided to assist in decisionmaking along with a patient’s values and preferences. The estimated time to complete this activity, including review of the materials is 1.0 hour(s).

This online CME activity, in slide talk format covers data from a systematic review conducted to determine the comparative effectiveness, benefits, and adverse effects of angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and direct renin inhibitors (DRIs) for adults with hypertension. This CME activity is provided to assist in decisionmaking along with a patient’s values and preferences. The estimated time to complete this activity, including review of the materials is 1.0 hour(s).

This online CME activity, in slide talk format is from Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update, Comparative Effectiveness Review No. 27, prepared by the Johns Hopkins University Evidence-based Practice Center under Contract No. 290-02-0018 for the Agency for Healthcare Research and Quality, March 2011. In 2007, AHRQ published its first systematic review on the comparative effectiveness of oral medications for type 2 diabetes. In 2011, this review was updated to include newer medications and combination therapies. The estimated time to complete this activity, including review of the materials, is 1.0 hour(s).

This online CME activity, in case study format is from Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update, Comparative Effectiveness Review No. 27, prepared by the Johns Hopkins University Evidence-based Practice Center under Contract No. 290-02-0018 for the Agency for Healthcare Research and Quality, March 2011. In 2007, AHRQ published its first systematic review on the comparative effectiveness of oral medications for type 2 diabetes. In 2011, this review was updated to include newer medications and combination therapies.This case study will seek to evaluate monotherapy and two-drug combination therapies for the management of an adult with type 2 diabetes. The estimated time to complete this activity, including review of the materials, is 0.75 hour(s).

This online CME activity, in slide talk format is from Pain Management Interventions for Hip Fracture, Comparative Effectiveness Review No. 30, prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-02-0023 for the Agency for Healthcare Research and Quality, May 2011. This systematic review and meta-analysis evaluated the evidence for the effectiveness and safety of pain management interventions used for elderly patients with hip fracture. The estimated time to complete this activity, including review of the materials, is 1.0 hour(s).

This online CME activity, in slide talk format is from Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders, Comparative Effectiveness Review No. 26, prepared by the the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I for the Agency for Healthcare Research and Quality, April 2011. This systematic review and meta analysis evaluated the level of evidence currently available to support the effectiveness and safety of therapies for children with autism spectrum disorders. The estimated time to complete this activity, including review of the materials, is 1.0 hour(s).

This activity reviews the impact that CYP2C19 polymorphisms and drug interactions may have on patient response to clopidogrel therapy. This slide set reviews: the clopidogrel activation pathway, key genetic factors believed to influence the activation of clopidogrel, and recently published data regarding the clinical significance of clopidogrel resistance imparted by either genetic factors or interactions with proton pump inhibitors. Perspectives are provided regarding the clinical implications and challenges resulting from diminished response to clopidogrel in the context of published evidence; medical society statements, recommendations, and guidelines; and the FDA’s position on this issue. The estimated time to complete this activity, including review of the materials, is 1.0 hour(s).

This online CME activity, in slide talk format, was developed from Coleman CI, Baker WL, Kluger J, Reinhart K, Talati R, Quercia R, Mather J, Giovenale S, White CM. Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Stable Ischemic Heart Disease. Comparative Effectiveness Review No. 18. (Prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center under Contract No. 290-2007-10067-I.) Rockville, MD: Agency for Healthcare Research and Quality. October 2009. The estimated time to complete this activity, including review of the materials, is 1.0 hour(s).

This series of 13 online CME activities focuses on familiarizing investigators and clinicians interested in systematic review methods, with the methodological framework and guidance outlined in the AHRQ Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews. These CME activities have been approved for AMA PRA category 1 credit.^TM